View Journal Article: Physicochemical Evaluation of Bioactive Polymeric Composites Based on Hybrid Amorphous Calcium Phosphates
Citation:
Skrtic, D., Antonucci, J. M., Eanes, E. D., Eichmiller, F. C. and Schumacher, G. E. (2006). Physicochemical Evaluation of Bioactive Polymeric Composites Based on Hybrid Amorphous Calcium Phosphates. This article is a US Government work and, as such, is in the public domain in the United States of America.53 (4). 381-391.
Amorphous calcium phosphate (ACP)-filled methacrylate composites were recently found to effectively remineralize in vitro caries-like enamel lesions. Their inferior mechanical
properties compared to glass-filled composites, however, limit their use as a dental restorative material. In this study, the feasibility of introducing glass-forming elements (tetraethoxysilane or
zirconyl chloride) during the low-temperature synthesis of ACP was investigated. Composites based on such hybrid fillers (mass fraction, 40%) were evaluated to establish whether hybridization
strengthened the composites via improved interfacial interactions with the polymer phase without compromising the release of the mineral ions. Two types of visible-light cured resins were prepared:
BTHZ resin from 2,2-bis[p-(2’-hydroxy-3’- methacryloxypropoxy)phenyl]propane (BisGMA), triethylene glycol dimethacrylate (TEGDMA), 2-hydroxyethyl methacrylate (HEMA) and zirconyl methacrylate
(ZrM), and TP resin from TEGDMA and pyromellitic glycerol dimethacrylate (PMGDM). Hybridized fillers and BTHZ- and TP-based composites were characterized by the IR spectroscopy, X-ray diffraction,
dissolution/transformation kinetic studies, and biaxial flexure strength (BFS) testing before and after immersion in buffered saline solutions. The feasibility of improving the BFS via
hybridization, while retaining, if not enhancing the remineralizing potential was demonstrated for BTHZ-based composites. Both BFS and remineralizing ability of the TPcomposites, however,
deteriorated upon their exposure to an aqueous environment. Therefore, hybridized ACP-filled BTHZ composites have a potential for utilization in more demanding restorative, sealant, and adhesive
applications.
Publisher
Wiley Periodicals, Inc.
Date
2006-11-01
Copyright Notice
Array
Journal
This article is a US Government work and, as such, is in the public domain in the United States of America.
Volume
53
Pages
381-391
Issue
4
Copyright Agreement
on
Additional Notes
Journal of Biomedical Materials Research 2000; 53(4): 381-391.; Sponorship: Support for this work from the National Institute of Standards and Technology and the grant from the
American Dental Association Health Foundation are gratefully acknowledged.
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View Journal Article: Physicochemical Evaluation of Bioactive Polymeric Composites Based on Hybrid Amorphous Calcium Phosphates 